Animal models have long been utilized for pre-clinical studies, providing valuable insights into disease pathobiology and therapeutic development. Nevertheless, these models have constraints in faithfully reproducing the intricacies of human biology and the advancement of diseases. In addition, experiments on animal models can be costly and time-consuming. To address these challenges, Creative Biolabs offers a range of services to develop in vitro co-culture models that incorporate human lesion cells. These models offer a more cost-effective and efficient alternative for studying diseases, enabling researchers to conduct targeted and meaningful studies. With our expertise and cutting-edge platform, we are committed to supporting global customers in their research and therapeutic development efforts.

Fig.1 The communication between different types of macrophages and cancer cells in the tumor microenvironment.¹

In Vitro Coculture Model Development Services at Creative Biolabs

Creative Biolabs offers advanced in vitro coculture models that serve as valuable tools for investigating disease mechanisms and evaluating the effectiveness and safety of therapeutic interventions. We achieve desirable modes by directly or indirectly coculturing macrophages with other cells. Our services are compatible with multiple cell types such as T cells, endothelial cells, fibroblasts, and many others. Both primary cells and cell lines are applied to develop targeted coculture models.

Fig.2 Simplified illustration of our coculturing strategies.

In addition, we offer various advanced technologies for the analysis and verification of coculture models. If you have unique requirements, our experienced specialist team is willing to provide support for optimal and customized model development schemes. Importantly, Creative Biolabs' efficient 2D and 3D models help you generate reliable data while saving time and resources.

Design and implement personalized models tailored to the specific needs of your research projects, the services that we are able to provide include:

• Macrophage-Organoid Coculture Model Development Service
• Macrophage-Enteroid Coculture Model Development Service
• Macrophage-Endothelial Cell Coculture Model Development Service
• Macrophage-Smooth Muscle Cell Coculture Model Development Service
• Macrophage-Fibroblast Coculture Model Development Service
• Macrophage-T Cell Coculture Model Development Service
• Macrophage-Adipocyte Coculture Model Development Service
• Macrophage-Hepatocyte Coculture Model Development Service
• Macrophage-Epithelial Cell Coculture Model Development Service
• Macrophage-Mesenchymal Stem Cell Coculture Model Development Service
• Tumor-associated Macrophage and Cancer Cell Coculture Model Development Service

Benefits for You

• User-friendly.
• More closely resembles the clinical presentation of a patient's illness.
• High-throughput screening for large-scale therapeutic evaluation.
• Consistent and dependable.
• Routine and consistent reporting distribution.

Potential Applications

• Explore the intricate interplay among cells within in vitro coculture models.
• Conduct experiments using various treatment options on cells derived from patients.
• Assess and analyze the effectiveness of various immunotherapy strategies.
• Analyze the performance of experimental treatments.
• Analyze the gene expression profiles of potential immunotherapy targets or identify specific antigens of interest.
• Explore how medications work and the development of drug resistance in an individualized fashion.

Creative Biolabs offers a state-of-the-art in vitro biology platform that can accelerate your model development and drug discovery programs. Contact us for further details and assistance tailored to your project requirements.