Macrophage Engineering Service for Drug Delivery
Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can target cancerous cells, and therefore, can be engineered as drug carriers for tumor therapy. As a leading specialist in engineering macrophages, Creative Biolabs provides comprehensive R&D services of engineering M1 macrophages, macrophage-derived exosomes, and macrophage membrane as drug carriers.
Background of Engineering Macrophage for Drug Delivery
Macrophages are immune cells involved mainly in innate and adaptive immunity. In response to inflammation, macrophages are activated. They concentrate at the inflammation site to phagocytose and digest cell debris and pathogens, as well as activate lymphocytes or other immune cells. A large number of macrophages infiltrates the tumor microenvironment, significantly affecting tumor growth and metastasis. These properties make them good carriers of small-molecule drugs, proteins and nucleic acids. Long circulation time, abundant surface receptors, and active targeting ability of macrophages are the main advantages of biomimetically modified macrophage-based drug delivery systems. These delivery systems show great potential to overcome the short cycle time, low biocompatibility, and undesirable immunogenicity of common carrier materials. In recent years, the applications of macrophages as drug carriers with different properties have been significantly expanded.
Fig.1 Applications of macrophage engineering service for drug delivery.
Engineering Macrophage for Drug Delivery at Creative Biolabs
Given the role of macrophages in the tumor microenvironment, proinflammatory M1 macrophages can target tumors and phagocytose cancer cells. With an experienced team of in-house experts at macrophage development, Creative Biolabs has engaged in the development of macrophage-mediated drug delivery systems for many years. Our scientists have sought to utilize macrophages as drug carriers. Since the targeting of M1 macrophages comes from their surface membrane proteins, macrophage-derived exosomes can inherit the targeting ability of macrophages. Moreover, macrophage membranes can be extracted and engineered to coat different NPs to increase their targeting ability.
Integrating state-of-the-art technologies as well as industry-leading expertise, Creative Biolabs is committed to 1) Engineering Macrophages as Drug Carriers, 2) Engineering Macrophage-Derived Exosomes as Drug Carriers, and 3) Engineering Macrophage Membrane as Drug Carriers. Our seasoned scientists will work together closely to address these scientific and technical challenges.
Fig.2 State-of-the-art technologies for macrophage engineering.
Advantages of Mediated Drug Delivery System
-
Prolongation of drug circulation time and half-life
-
Good biocompatibility and biodegradability
-
Improvement of drug stability and drug targeting ability
-
Low immunogenicity
-
Sustained drug release
-
Delivery of various substances
Creative Biolabs is proud to offer the most comprehensive services of engineering M1 macrophages, macrophage-derived exosomes, and macrophage membrane for drug delivery. For more detailed information, please feel free to contact us or send us your inquiry.
