Engineering Approach
Cytokine Gene Overexpression-Lentivirus
Alternative Names
IL12; IL-12; Interleukin 12
Introduction
Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B lymphocytes. IL-12 induces cytokine production, primarily of IFN-gamma, from NK and T cells, acts as a growth factor for activated NK and T cells, enhances the cytotoxic activity of NK cells, and favors cytotoxic T lymphocyte generation.
Applications
Positive regulator of M1 polarization of macrophage; Improve survive; Promote persistence and activation of endogenous or adoptively transferred NK or T cells.
Reference
Brempelis, Katherine J., et al. "Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses." Journal for immunotherapy of cancer 8.2 (2020).
Datasheet