Creative Biolabs offers a comprehensive macrophage-T cell interaction analysis service designed to further understand the important relationship between macrophages and T cells. Both macrophages, which present antigens to T cells and activate them, and T cells, which affect the antigen presentation and activation of macrophages, play a vital role in maintaining the immune system. Disruptions to this process can lead to immunodeficiency or autoimmunity, making deep research on their interaction urgent. Creative Biolabs' macrophage-T cell interaction analysis has the capacity to serve for the development of associated therapeutic drugs. Paired with our well-established platform and professional team, we are confident in rapidly achieving your interaction analysis projects.

Fig.1 Monocyte/macrophage regulates CD4+ T cell response in inflamed RA joint.¹

Macrophage-T Cell Interaction Analysis Service at Creative Biolabs

At Creative Biolabs, our comprehensive macrophage-T cell interaction analysis service is designed to enhance the understanding of cellular interaction, driving forward the development of immune therapeutic drugs with our state-of-the-art technology and experienced team. We not only offer a suite of methods but also deliver custom solutions for analyzing the complex interaction between macrophages and T cells. Using these diversified techniques, we have the ability to explore the interaction between macrophages and T cells from a multitude of angles such as gene expression and relative location.

In addition, different subsets of T cells exert effects on macrophage polarization, and we also offer macrophage polarization assay services to examine how their interaction affects macrophage polarization. We are glad to work with you to discover and develop novel therapeutic drugs or therapies targeting macrophage-T cell interaction.

Diverse Approaches

Here we provide a range of analysis approaches to design for global customers' significant macrophage-T cell interaction analysis projects:

Benefits for You

• Ph.D. research team.
• Alternative experiment designs cater to your diverse needs.
• High-throughput, sensitive, cell-friendly approaches.
• Customized comprehensive services.

Publication

With the understanding that HIV infecting macrophages can alter podosomes and increase surface area, scientists hypothesized that these morphological shifts could escalate the rate of contact with T cells, thereby boosting viral transmission. To test this theory, a live-cell imaging method was employed, embedding macrophages and in vitro-grown, autologous CD4+ T cells into a 3D collagen matrix. Findings indicated that the interaction between HIV-infected macrophages and T cells leads to an increase in T cell immobilizing or scanning behaviors in more than half of all encountered interactions.

Fig.2 The interaction between macrophage and T cell in 3D collagen.²

If you want to get more information about our macrophage-T cell interaction analysis service, please contact us without hesitation.