As a heterogeneous population of immune cells, macrophages provide crucial innate immune defense and play several and diverse functions in homeostatic and immune responses. Creative Biolabs combines deep, industry-leading expertise with innovative platforms to provide a full range of high-quality services to support macrophage therapeutics development. With an experienced team of in-house experts, we have developed a consultative strategy to provide our clients with a highly customizable solution. Our scientists are pleased to share our advanced technology and extensive expertise in macrophage therapeutics development.

Functions of Macrophages

Featured by remarkable plasticity, macrophages change their physiology in response to various environmental stimuli. They can be classified into two extremes: a pro-inflammatory (M1) and an anti-inflammatory/pro-resolving (M2) profile. M1 population occur after exposure to microbial antigens and are able to start and sustain inflammatory responses, secret pro-inflammatory cytokines, such as interferon-γ (IFN-γ), activate endothelial cells, and recruit other immune cells into the inflamed tissue. On the other hand, M2 macrophages promote the resolution of inflammation, phagocytose apoptotic cells, drive collagen deposition, coordinate tissue integrity, and release anti-inflammatory mediators. These specialized cells have an enhanced cytotoxic phenotype and play central roles in a wide range of diseases, such as cancers, autoimmune diseases, cardiovascular diseases, and tuberculosis.

Service Portfolios for Macrophage Therapeutics Development at Creative Biolabs

Creative Biolabs is a well-recognized leader in the field of immuno-oncology. Equipped with a team of seasoned scientists with facilities designed specifically to meet every challenging requirement in macrophage therapeutics development, we offer fast, reliable support for any phase of macrophage therapeutics development. Based on our advanced macrophage therapeutics development platform, our scientists provide a comprehensive portfolio including macrophage isolation and culture service, macrophage polarization assay, macrophage polarization phenotype identification and characterization service, macrophage reprogramming service, macrophage-targeted drug delivery system development, macrophage engineering service for drug delivery, and macrophage marker development service.

Highlights

• Polarization phenotype can be identified with unique characteristics.
• Characterization of each macrophage population may help to explain disease aetiologies.
• Reprogramming tumor-associated Macrophage (TAM) by different strategies.
• Engineering macrophage for therapeutics delivery.
• The identification of markers may allow us to delete specific populations of macrophages, or for diagnostic purposes.

Scientists at Creative Biolabs are versed in macrophage therapeutics development. We are glad to serve our global clients with professionalism and expertise. Our comprehensive portfolio provides reliable support to help our clients' macrophage therapeutics development projects. For more detailed information, please feel free to contact us or send us your inquiry or question.