As a heterogeneous population of immune cells, macrophages provide crucial innate immune defense and play several and diverse functions in homeostatic and immune responses. Creative Biolabs combines deep, industry-leading expertise with innovative platforms to provide a full range of high-quality services to support macrophage therapeutics development. With an experienced team of in-house experts, we have developed a consultative strategy to provide our clients with a highly customizable solution. Our scientists are pleased to share our advanced technology and extensive expertise in macrophage therapeutics development.

Overview of Macrophage Therapeutics

Featured by remarkable plasticity, macrophages change their physiology in response to various environmental stimuli. They can be classified into two extremes: a pro-inflammatory (M1) and an anti-inflammatory/pro-resolving (M2) profile. M1 population occur after exposure to microbial antigens and are able to start and sustain inflammatory responses, secret pro-inflammatory cytokines, such as interferon-γ (IFN-γ), activate endothelial cells, and recruit other immune cells into the inflamed tissue. On the other hand, M2 macrophages promote the resolution of inflammation, phagocytose apoptotic cells, drive collagen deposition, coordinate tissue integrity, and release anti-inflammatory mediators. These specialized cells have an enhanced cytotoxic phenotype and play central roles in a wide range of diseases, such as cancers, autoimmune diseases, cardiovascular diseases, and tuberculosis.

Therapeutic Applications of Macrophages

Service Portfolios for Macrophage Therapeutics Development at Creative Biolabs

Creative Biolabs is a well-recognized leader in the field of immuno-oncology. Equipped with a team of seasoned scientists with facilities designed specifically to meet every challenging requirement in macrophage therapeutics development, we offer fast, reliable support for any phase of macrophage therapeutics development. Based on our advanced macrophage therapeutics development platform, our scientists provide a comprehensive portfolio including macrophage isolation and culture service, macrophage polarization assay, macrophage polarization phenotype identification and characterization service, macrophage reprogramming service, macrophage-targeted drug delivery system development, macrophage engineering service for drug delivery, and macrophage marker development service.

Highlights

• Polarization phenotype can be identified with unique characteristics.
• Characterization of each macrophage population may help to explain disease aetiologies.
• Reprogramming tumor-associated Macrophage (TAM) by different strategies.
• Engineering macrophage for therapeutics delivery.
• The identification of markers may allow us to delete specific populations of macrophages, or for diagnostic purposes.

Scientists at Creative Biolabs are versed in macrophage therapeutics development. We are glad to serve our global clients with professionalism and expertise. Our comprehensive portfolio provides reliable support to help our clients' macrophage therapeutics development projects. For more detailed information, please feel free to contact us or send us your inquiry or question.

Related Products

Creative Biolabs designs and develops a range of useful products to assist customers in macrophage therapy development, cell therapy research and disease modeling. Our comprehensive portfolio includes monocytes, macrophages, culture reagents, differentiation reagents, assay kits, viral vectors, and other related products that contribute to our customers' research.

In the table below, we have provided some popular products that you can click to view the details.

Service Features

Scientific Resources

Q & A

Q: What sample types can you work with for macrophage research?
A: We are able to work with a wide range of sample types for macrophage-related studies, including primary cells isolated from human, mouse, or rat tissues, as well as immortalized macrophage cell lines. Our team has extensive experience handling and processing various sample types to ensure the integrity of your macrophage samples throughout the research workflow.

Q: Can you help me with custom macrophage-related assay development?
A: Absolutely. We understand that your research may require specialized or unique macrophage-related assays. Our team of experts is well-versed in assay development and optimization, and we would be happy to work closely with you to design and validate custom macrophage assays tailored to your specific research objectives. We can provide guidance on experimental parameters, analytical techniques, and data interpretation to ensure the success of your custom assay project.

Q: Can you provide macrophage samples from different disease models or conditions?
A: Yes, we have access to a broad range of macrophage samples from various disease models and pathological conditions. This includes samples from models of inflammation, infection, cancer, metabolic disorders, and more. Our extensive products allow us to provide you with well-characterized macrophage samples that can help you investigate the role of these cells in the context of your specific research interests.

Q: How long does it usually take to complete a macrophage-related research project?
A: Project timelines depend on the complexity of your research needs. For basic assays such as cytokine analysis, we can provide results in a short period of time. More complex services, such as custom macrophage model development or gene editing, may take longer. We always work closely with our clients to provide realistic timelines and progress updates throughout the project.