Macrophage Model Development Services

Macrophages play a crucial role in the immune system, functioning as key players in the body's defense against pathogens and tissue repair processes. Creative Biolabs has developed different types of macrophage models to provide a one-stop solution for a wide range of studies, including immune response, drug development, and disease mechanisms.

Macrophage Model: Contributing to Our Understanding of Immune Responses and Disease Pathogenesis

In vitro macrophages exhibit phenotypic plasticity, meaning they can adopt different activation states (M1, M2, etc.) in response to microenvironmental cues.
In vitro macrophage models enable the investigation of various macrophage functions, including phagocytosis (uptake of particles or pathogens), cytokine secretion (such as TNF-α, IL-6), antigen presentation, and immune modulation.
In co-culture or conditioned media experiments, in vitro macrophage models can be used to study interactions between macrophages and other immune cells, such as T cells, B cells, dendritic cells, or stromal cells.
Infection models using pathogens (bacteria, viruses, parasites) allow researchers to study host-pathogen interactions and immune responses. This helps in understanding mechanisms of pathogen recognition, phagocytosis, intracellular killing, and immune evasion strategies.

Fig.1 Macrophage model activation. (Hao, et al., 2021) Fig.1 M1/M2 model of macrophage activation.¹

Macrophage Model Development Services at Creative Biolabs

Different Models at Creative Biolabs

We offer, but are not limited to, the following macrophage models:

THP-1-based Macrophage Model	RAW 264.7-based Macrophage Model	U937-based Macrophage Model	HL-60-based Macrophage Model	KG-1-based Macrophage Model	HEL-based Macrophage Model
Creative Biolabs has established a THP-1-based macrophage model service to provide a versatile and accessible platform for macrophage biology research.	Creative Biolabs specializes in the development of RAW 264.7-based macrophage models for research purposes, and our scientists and technology platform with expertise in macrophage cell culture and model development.	Creative Biolabs develops U937-based macrophage models to provide quality-controlled cell models and characterization services for your biomedical research.	Creative Biolabs has developed HL-60-based macrophage models, providing a valuable experimental system for elucidating the biology of macrophages and their role in health and disease.	Creative Biolabs develops a macrophage model based on KG-1 cells, which consists of culturing and inducing differentiation into macrophage-like cells.	Creative Biolabs, dedicated to exploring the latest developments in the field of macrophages, has launched a HEL-based macrophage model development service.

If you don't see any of the macrophage models you're interested in, feel free to contact our scientists directly for more options!

In Vitro Coculture Model Development Services
Leveraging our deep expertise in cell biology and tissue engineering, we provide an end-to-end service that includes model design, cell validation, optimization of culture conditions, data analysis, and interpretation of results. Our services encompass the selection and validation of high-quality cell lines, the development of optimized culture media suitable for the growth and interaction of various cell types, and the integration of advanced technologies such as microfluidics and 3D culture systems to create dynamic and physiologically relevant environments. Through these services, we enable researchers to delve deeper into cell-cell interactions, disease mechanisms, and drug effects, thereby advancing cutting-edge scientific research and the development of new therapies.
Cell Services at Creative Biolabs
- Cell Culture and Differentiation
- Cell Phenotype Identification and Characterization
- Genetic Engineering
- Disease Modeling
  Developing macrophage models of specific diseases, such as cancer, infectious diseases, or autoimmune disorders.
- Drug Screening Assays

Developing high-throughput screening assays using macrophage models to evaluate the efficacy and safety of potential therapeutic compounds.

You can choose the service you need based on your specific macrophage project, or directly click on the keyword to learn more!

Advantages of Our Cells

Based on continuous exploration in the field of macrophages, Creative Biolabs' scientists have a deep understanding of macrophages from different sources. Through the discovery of advanced technologies and extensive experience in cell therapy, we bring a comprehensive service offering to your macrophage project, in addition to macrophage models, you can click here to learn more.

Reference

Hao, Xiaopei et al. "Targeting immune cells in the tumor microenvironment of HCC: New opportunities and challenges." Frontiers in cell and developmental biology. (2021) 9 775462.