Macrophages are an essential component of the innate immune system and are highly specialized in protecting the body against invaders. Macrophage has a significant role in several disorders. Tumor-associated macrophages (TAMs), as a special type of macrophages, play a significant role in several disorders and cancers. They usually facilitate the development and spread of tumors by stimulating angiogenesis, immunosuppression, and cancer cell proliferation. Clinically, several cancers have a worse prognosis when TAMs are present inside the original tumor. Accordingly, targeting TAMs in drug development is expected to lead to substantial breakthroughs in cancer therapy.

Fig.1 Role of TAMs in tumor development.^1,2

Anti-TAM Drug Development Services at Creative Biolabs

Targeting different pathways of TAM contributes to cancer formulation. Creative Biolabs developed a series of anti-TAM drug development services to aid in anti-cancer drug development, mainly including:

Drug Development Service Targeting Phagocytosis Promotion of TAM

Enhancing the phagocytic activity of TAMs is emerging as a promising approach for cancer treatment. Our approach focuses on targeting the signals that inhibit phagocytosis, to reduce their expression and thereby promote the phagocytosis of TAMs.

Drug Development Service Targeting TAM Depletion

The development of malignancy may be successfully inhibited by the selective consumption of M2-like TAMs in pharmacological therapy. To deplete TAMs, we hunt for many signals that are part of pathways that either prevent M2-TAM formation or make M2-TAMs more apoptotic.

Drug Development Service Targeting TAM Recruitment Blocking

Many elements in the tumor microenvironment (TME) affect the recruitment of M2-like TAMs to the tumor site. One strategy for anti-cancer targeting TAMs could be to stop them from recruiting M2-like TAMs. To find novel medications that inhibit TAM recruitment, we focus on the signals that are associated with tumor formation and TAM recruitment.

Drug Development Service Targeting TAM Reprogramming

TME cytokines cause TAMs to transition from M1-like to M2-like, which in turn drives immune suppression and accelerates tumor growth. Therefore, as a novel and effective anti-cancer therapy approach, we attempt to re-educate M2-like TAMs into M1-like TAMs by targeting similar signals.

Drug Development Service Targeting TAM Metabolism

Disrupting the metabolic shift of TAMs, including changes to their glucose, amino acid, and lipid profiles, may reduce macrophages' capacity to support tumor development, metastasis, and the establishment of an immunosuppressive microenvironment. We aim to disrupt the formation of an immunosuppressive milieu by influencing the metabolic profile.

Tab.1 Hot targets in drug development strategies.

Related Products

In the field of anti-TAM drug discovery, researchers are constantly striving to find new ways to target the tumor microenvironment and inhibit tumor growth and metastasis. Our R&D services are designed to provide comprehensive support to our clients, from early drug discovery to preclinical studies.

In the process, we not only provide customized research solutions, but also utilize the latest technologies and research products to help you fast-track your projects. With our products, you can realize a more efficient research process and increase the success rate.

Service Features

Workflow of Anti-TAM Drug Development Services

Scientific Resources

Learn More Macrophages in Diseases

Download M1 vs. M2 Macrophages

Learn More Different Approaches to Regulating Polarization of Tumor-Associated Macrophages

Learn More Isolation and Identification of Macrophages

Q & A

Q: What is the typical cost of TAM drug development? Is there a fixed cost rate?

A: Costs will vary depending on the complexity of the project, the stage of research required, and the duration. We provide personalized quotes based on specific needs and try to stay within a reasonable budget. We will communicate with you in detail about the fee structure and ensure transparency before the project begins.

Q: Can I stay informed of progress during the partnership?

A: Absolutely! We schedule regular meetings and progress reports to make sure you are kept up to date with every stage and milestone of your project. If you have any questions or need further information, our team is always ready to answer them.

Q: Can I make any changes or suggestions to the drug during the development process?

A: Of course you can. We are very open to feedback and suggestions from our customers. Your ideas and needs are our top priority at any stage of the project. Our goal is to ensure that the final drug developed meets your expectations and the needs of the market.

Q: Does your team have expertise in dealing with specific disease areas?

A: We have a multidisciplinary team of experts covering a wide range of disease areas, including endocrinology, cancer, immunology, and more. If you have a need for a specific disease, we will target-match the relevant team of experts to ensure the science and effectiveness of the program.