Drug Development Service Targeting TAM Metabolism

Targeting TAM Metabolism for Cancer Therapy

Tumor-associated macrophages (TAMs) are a significant part of immune infiltration in solid malignancies. They play roles in every stage of neoplastic development in patients, from the beginning to the end. Throughout the process, TAMs undergo modifications in their metabolic profiles to support tumor development, metastasis, and the creation of an immunosuppressive microenvironment. Therefore, learning more about TAM metabolism is significant for controlling tumor development.

Fig.1 Metabolic alterations in TAMs.¹

Our Drug Development Service Targeting TAM Metabolism

Creative Biolabs succeeded in developing a low-cost and robust drug development service targeting TAM metabolism to boost drug development in cancer therapy. In our service, we mainly target the metabolic profile of TAM to discover novel therapeutic drugs. Specifically, we provide several targets in terms of different metabolic pathways and develop specific drug types to meet global customers' distinctive demands. At Creative Biolabs, we promise that we will deliver high-quality outcomes to global customers in a short time.

Popular Targets

Here we list several popular targets in our drug development service targeting TAM metabolism:

Glucose metabolism	Hexokinase 2; Lactate dehydrogenase; MCT; PKM2
Lipid metabolism	SREBP; CPT1; FASN; Caspase-1/PPARγ; ABCA1/ABCG1
Amino acid metabolism	AHR; GLS1/2 glutamine; Glutamine synthetase; Arginase
Glucose metabolism AND Lipid metabolism	AMPK/mTOR; SREBP/PARP; NHE1; PDK

Diverse Drug Types

Fig.3 Diverse Drug Types. (Creative Biolabs Original)

Key Advantages

A Variety of Drug Development Services
We provide a variety of targets that are engaged in various pathways, and we can develop a wide range of medication kinds to meet the needs of consumers throughout the world.
Professional Research Team
We provide each project with a qualified research team to ensure its success.
Quick Schedules
We can quickly provide outcomes that each consumer will find satisfactory.
One-stop Customized Services
We provide comprehensive, personalized services to satisfy the various demands of customers throughout the world.

Work with Creative Biolabs

As a service provider with years of experience in the field of tumor immunity, Creative Biolabs insists on providing high-quality solutions to every customer. Here we deliver an inquiry mode to get in touch with us for more information about our drug development service targeting TAM metabolism.

Reference

Xiao, Li, et al. "Tumor-associated macrophages: new insights on their metabolic regulation and their influence in cancer immunotherapy." Frontiers in Immunology 14 (2023): 1157291.