Tumor-associated macrophages (TAMs) are a significant part of immune infiltration in solid malignancies. They play roles in every stage of neoplastic development in patients, from the beginning to the end. Throughout the process, TAMs undergo modifications in their metabolic profiles to support tumor development, metastasis, and the creation of an immunosuppressive microenvironment. Therefore, learning more about TAM metabolism is significant for controlling tumor development.
Fig.1 Metabolic alterations in TAMs.1
Creative Biolabs succeeded in developing a low-cost and robust drug development service targeting TAM metabolism to boost drug development in cancer therapy. In our service, we mainly target the metabolic profile of TAM to discover novel therapeutic drugs. Specifically, we provide several targets in terms of different metabolic pathways and develop specific drug types to meet global customers' distinctive demands. At Creative Biolabs, we promise that we will deliver high-quality outcomes to global customers in a short time.
Here we list several popular targets in our drug development service targeting TAM metabolism:
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Hexokinase 2; Lactate dehydrogenase; MCT; PKM2 |
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SREBP; CPT1; FASN; Caspase-1/PPARγ; ABCA1/ABCG1 |
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AHR; GLS1/2 glutamine; Glutamine synthetase; Arginase |
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AMPK/mTOR; SREBP/PARP; NHE1; PDK |
Currently, there are several researches focused on TAM metabolism that has boosted the development of associated drugs targeting TAM metabolism processes particularly metabolisms of glucose, amino acids, and lipid. By targeting different metabolism-relevant targets, many drugs have been employed in the treatment of cancer and other disorders, which also exhibit a significant regulatory effect on TAM metabolism processes.
Fig.2 TAM metabolism-targeting agents.2
As a service provider with years of experience in the field of tumor immunity, Creative Biolabs insists on providing high-quality solutions to every customer. Here we deliver an inquiry mode to get in touch with us for more information about our drug development service targeting TAM metabolism.
References
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