Macrophage-B Cell Interaction Analysis Service

The Interaction Between Macrophages and B Cells: A Novel Insight for Therapeutic Development

Macrophages, as essential immune effector cells, play a crucial role in maintaining immune homeostasis and facilitating immune responses. They have the ability to interact with B cells, a type of lymphocyte, which further enhances immune responses. However, these interactions can sometimes contribute to the development of a tumor-promoting environment. Accordingly, by studying and targeting the specific interactions between macrophages and B cells, researchers can gain valuable insights into the immune system and develop novel immunotherapies. Creative Biolabs offers a specialized macrophage-B cell interaction analysis service to investigate the dynamic interactions between these two cell types in the immune system, assisting in the discovery and development of innovative therapeutic approaches.

Fig.1 The interaction between M2-like cells and B cells contributes to macrophage polarization.¹

Macrophage-B Cell Interaction Analysis Service at Creative Biolabs

Creative Biolabs' macrophage-B cell interaction analysis service focuses on the interactions between these two cells, which is useful for researchers to deeply understand the mechanism of the immune system and sheds light on the development of disease diagnosis and treatment. We provide multiple types of approaches to analyze the interaction between macrophages and B cells. Every approach is unique and possesses its application range. Therefore, we also provide a custom solution development service to enable customers' projects. With these distinctive approaches, we are able to analyze the interaction between macrophages and B cells from different aspects such as influencing factors, gene expression, and relative location.

In addition, biomarkers are crucial for our macrophage-B cell interaction service, and we simultaneously deliver a series of distinctive biomarkers for customers to choose from for your meaningful projects. Equipped with our robust macrophage therapeutics development platform and experienced research teams, our macrophage-B cell interaction analysis service will answer every customer with a desirable high-quality finding.

Diverse Approaches

Here we display several alternative approaches to support global customers' projects:

Co-culture experiment: Macrophages and B cells were co-cultured in different experimental conditions to investigate the impact of factors on their interaction.
Immunofluorescence microscopy: a technique that uses fluorescently labeled antibodies to visualize and study the spatial distribution and interaction between macrophages and B cells in tissues or organs.
Flow cytometry: A high-throughput research tool used to analyze and quantify cellular characteristics, such as surface markers and cytokine expression, in macrophages and B cells. It provides valuable insights into the interaction mechanisms between these two cell types.
Gene knockout or transgenic technology: This technology is used to disrupt or introduce specific genes in macrophages or B cells, allowing researchers to study the impact of these genes on the interaction between the two cell types and to investigate their functional roles in this interaction.
Animal model: Injecting macrophages or B lymphocytes into animals allows for the study of their interaction and influence in vivo.

Popular Biomarkers

Popular Biomarkers
B cells	Macrophages
CD19, CD20, CD21, CD22, CD23, etc.	CD68, CD80, CD86, CD169, CD21, CSF-1R, IL-1, IL-6, TNF-α, ICAM-1/VCAM-1, etc.

For more details about our macrophage-B cell interaction service, please feel free to get in touch with us. Welcome your inquiry and order.

Reference

Biswas, Subhra K., and Alberto Mantovani. "Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm." Nature Immunology 11.10 (2010): 889-896.