Focusing on Phagocytosis for Macrophage Therapeutic Development

As an essential part of the immune system, macrophages have the ability to engulf the tumor cells and release active chemicals to inhibit the development of tumors. Thus, the abnormal phagocytosis function of macrophages is closely associated with the occurrence of cancers. Creative Biolabs offers a phagocytosis capacity analysis service to help clients evaluate the phagocytosis capacity of macrophages. With this service, we aim to deliver more insights about macrophage therapeutics and boost drug development targeting macrophage phagocytosis.

Fig.1 The macrophage phagocytosis process.¹

Phagocytosis Capacity Analysis Service by FITC-Dextran Uptake Assay at Creative Biolabs

Phagocytosis capacity analysis service by FITC-dextran uptake assay from Creative Biolabs takes advantage of FITC-dextran to model pathogens and observe the ability of macrophages to phagocytose and digest these particles. We not only provide a macrophage phagocytosis capacity analysis service for diverse samples but also provide custom solutions to support your phagocytosis capacity analysis needs. In addition, we also deliver a service that helps customers isolate and culture macrophages to aid in achieving meaningful macrophage projects.

By the way, we have delivered a wide range of cost-effective drug development services targeting TAM to help global customers discover and develop novel macrophage-targeted compounds. At Creative Biolabs, we are confident in presenting high-quality and dependable outcomes for every customer together with our experienced research teams. We encourage customers to inquire and place orders.

Our phagocytosis capacity analysis service by FITC-dextran uptake assay is suitable for multiple types of samples:

• Adherent cells
• Suspension cells
• Bone marrow
• Peripheral blood mononuclear cells
• Spleen
• Others

Data Support

DATA: The researcher has utilized the FITC-dextran uptake assay to evaluate the phagocytosis capacity of macrophages from bone marrow, spleen, and peritoneum. These results show that bone marrow macrophage has the strongest phagocytic ability but macrophages derived from the peritoneum have stronger phagocytic capacity than macrophages from bone marrow and spleen based on the counting and fluorescence intensity observation of FITC-dextran taken up by macrophages from these three sources. This finding gives new insights into the phagocytic capabilities of macrophages from different sources.

Fig.2 Phagocytosis capacity of macrophages from bone marrow, spleen, and peritoneum.²

As a leading company in macrophage characterization, Creative Biolabs is constantly developing novel technology services to serve as useful tools for customers' diverse macrophage projects. If you want to know more details about our phagocytosis capacity analysis service by FITC-dextran uptake assay, please don't hesitate to contact us.

References

1. Li, Si-Yuan, et al. "Anti-Tumor Strategies by Harnessing the Phagocytosis of Macrophages." Cancers 15.10 (2023): 2717.
2. Wang, Changqi, et al. "Characterization of murine macrophages from bone marrow, spleen and peritoneum." BMC Immunology 14.1 (2013): 1-10.