Macrophage-targeted Drug Delivery System Development
Based on the unrivaled expertise and experiences in immunotherapy discovery and development, Creative Biolabs provides macrophage-targeted drug delivery systems development services for global clients to speed up the development of immunotherapy projects.
Introduction to Macrophage-targeted Drug Delivery Systems
Macrophages play a vital role in protecting the body against tissue damage and foreign pathogens by regulating the immune response. With the in-depth understanding of macrophages in recent years, more and more studies focus on macrophage-targeted drug delivery systems.
Based on the advancement in nanotechnology, different polymeric-based nanoparticles, dendrimers, functionalized nano cargoes, and lipid-based nano-drug delivery carriers have been applied to macrophage-targeted drug delivery systems.
Fig.1 Schematic representation of macrophage-mediated drug delivery approach.1,2
Macrophages as Targets of Drug Delivery System
Macrophages have been explored as potential targets of drug delivery systems based on several character:
-
The tropism to hypoxia and the ability to migrate and infiltrate into tumors.
-
Macrophages can specialize into two types M1, M2 macrophage possessing different functions, and the two types of cells express diverse targets on the surface.
-
Good biocompatibility and biodegradability.
-
Improvement of drug targeting ability.
Macrophage-targeted Drug Delivery Systems Development Service at Creative Biolabs
Based on the unrivaled expertise and experiences in immunotherapy discovery and development, Macrophage-targeted drug delivery system development services at Creative Biolabs include but are not limited to:
With profound expertise and a state-of-the-art Macrophage Therapeutics Development Platform, Creative Biolabs is committed to providing tailored services to each project to ensure that the objectives are met or exceeded. For further details, please don't hesitate to contact us and see how we can help you with your project.
References
-
Zhao, Yuling, et al. "GDNF-transfected macrophages produce potent neuroprotective effects in Parkinson's disease mouse model." PloS one 9.9 (2014): e106867.
-
Under Open Access license CC BY 4.0, without modification.
