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TNF-α Lentiviral Particle for Macrophage Engineering (MTS-0124-LX7)

Overview

Description
TNF-α is involved in serveral macrophage related functions, including as the positive regulator of M1 polarization of macrophage. The ready-to-use TNF-α Lentiviral Particle is packaged using 3rd generation of lentiviral packaging system, which is a research tool for macrophage cell engineering in vivo and in vitro.
Product Type
Virus Particles
Application Scenario
For in vivo and in vitro macrophage engineering

Target Specification

Engineering Approach
Cytokine Gene Overexpression-Lentivirus
Species
Human
Target
TNF-α
Alternative Names
DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Full Name
Tumor necrosis factor
Introduction
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
UniprotID
GeneID
Applications
Positive regulator of M1 polarization of macrophage
Reference
Brempelis, Katherine J et al. "Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses." Journal for immunotherapy of cancer vol. 8,2 (2020): e001356. doi:10.1136/jitc-2020-001356

Product Specification

Packaging System
Lentivirus
Titer
>1E8 TU/mL
Size
200uL; 1mL
Mycoplasma Testing
Negative
Sterility Testing
Negative
Shipping
Dry ice
Storage
Stored at -80°C for long term.
Handling Notes
Avoid multiple freeze/thaw cycles.
Restriction
RUO

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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