Engineering Approach
Checkpoint Antibody Seq Overexpression-Lentivirus
Target
Anti-CTLA4 antibody
Alternative Names
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
Full Name
Cytotoxic T-lymphocyte associated protein 4
Introduction
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Applications
Resistant to reprogramming by tumor-secreted signals
Reference
Brempelis, Katherine J et al. "Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses." Journal for immunotherapy of cancer vol. 8,2 (2020): e001356. doi:10.1136/jitc-2020-001356
Datasheet