The interaction between epithelial cells and macrophages is crucial in the body's immune response to inflammation and infection. Inflammatory mediators and matrix metalloproteinases (MMPs) released by these cells play a key role in tissue destruction at the site of inflammation. To better understand this interaction, Creative Biolabs offers a service to create a macrophage-epithelial cell coculture model in vitro. This model allows researchers to study the communication, signaling pathways, and inflammatory responses between these cell types, providing valuable insights into the development of vascular diseases and potential therapeutic interventions.

Macrophage-Endothelial Cell Coculture Model Development Service at Creative Biolabs

Utilizing cutting-edge tools and expertise in macrophage coculture, Creative Biolabs offers a macrophage-endothelial cell coculture model development service to aid in global customers' various macrophage projects. Our team assists customers in selecting suitable cell lines and coculture techniques.

In our macrophage-endothelial cell coculture model, macrophages play a crucial role in regulating the behavior of endothelial cells through the secretion of various signaling molecules. On the other hand, endothelial cells also influence the adhesion and activation of macrophages by expressing specific molecules and releasing growth factors. By closely studying the expression of these signaling molecules, cell morphological changes, and other markers in the coculture model under different conditions, we are able to gain valuable insights into inflammatory responses and disease pathogenesis. Moreover, this model enables the screening and evaluation of therapeutic compounds targeting the interaction between these cell types, as well as endows value for assessing immune therapeutic strategies. We encourage global customers to inquire and place your orders.

Fig.1 Macrophage-like functions in endothelial cells.¹

Coculturing Strategies Available at Creative Biolabs

• Direct co-culture: Macrophages and endothelial cells are seeded simultaneously or separately in the same well and cultured, so that these two cells are in direct contact.
• Indirect co-culture: Macrophages and endothelial cells are cultured separately on different surfaces and then brought together in the same growth medium, allowing the cells to interact and communicate without physically touching each other.

Key Advantages

• Industry-leading research team.
• A comprehensive assessment of macrophage-endothelial cell coculture model.
• Suitable for various species-derived and tissue-derived cells.
• Matured and robust platform supports.
• Rigorous quality control measures guarantee the traceability of data.
• Consistent adherence to reporting standards ensures efficient and accurate communication of findings.

Creative Biolabs is a leader in the field of cell biology and model construction, with a strong focus on developing advanced macrophage co-culture models. Our team's extensive experience ensures the successful design and implementation of macrophage-endothelial cell co-culture models for a wide range of research projects. If you are looking for innovative solutions and expert support in this area, feel free to contact us for more information.