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Rat Macrophages, bone marrow-derived (MTS-1223-HM13)

Overview

Description
Creative Biolabs offers rat macrophages are derived from bone marrow of normal rats by standardized methods.
Species
Rat
Product Type
Cell

Specification

Cell Source
Bone Marrow
Marker expression
F4/80 and CD11b/c positive
Size
1,000,000 cells

Product Disclaimer

Product Disclaimer
This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.
FAQs Customer Reviews Related Products

How well do the bone marrow-derived macrophages tolerate repeated stimulation or longer incubation times in culture?

Under recommended culture conditions, these macrophages maintain good viability and functionality over several days to a week. They can tolerate repeated stimulation with appropriate rest periods, but as with any primary cell type, excessive or prolonged activation may eventually lead to stress or cell death. For experiments involving long-term exposure or multiple rounds of stimulation, we suggest pilot studies to identify optimal schedules and concentrations. Our technical support team is available to help interpret your pilot results and refine your protocols.

Can these rat macrophages be used in co-culture systems with other rodent cell types, such as neurons or epithelial cells?

Absolutely. Many researchers integrate bone marrow-derived macrophages into co-culture models with rodent neurons, glial cells, or epithelial lines to explore cross-talk between immune and non-immune cells. When combining cell types, it is important to consider the medium composition and environmental conditions that support both populations.

What options are available if I need a consistent supply of these cells for a long-term project, such as a multi-year drug development program?

For long-term projects, we can work with you to establish a supply plan that ensures continuity and consistency. Options may include larger initial orders, scheduled production of new lots with comparable characteristics, or custom projects tailored to your specific requirements. Early communication about your projected usage, timeline, and key performance criteria allows us to align production and quality controls with your program needs, reducing the risk of interruptions or unexpected variability.

  • We rely heavily on rat models in our early drug development work, and having bone marrow-derived macrophages from the same species has been a big asset
    The cells consistently show robust responses to our test compounds and classic inflammatory stimuli. Their behavior aligns well with what we observe in our in vivo studies, which gives us more confidence in our in vitro findings.
  • We used these rat macrophages in a project focused on immunotoxicity
    They tolerated multiple sampling time points and repeated exposures to test articles. The viability and morphology remained stable over the course of the assays, and the cytokine data were reproducible. This reliability allowed us to run a fairly complex study design without being limited by the cells.
  • We use these cells in co-culture with rat neurons and astrocytes to study neuroinflammation
    The macrophages integrated well into our established culture system and contributed to the inflammatory environment in a way that resembles what we see in vivo. This has strengthened our in vitro models and given us more confidence in our screening data.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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