Under recommended culture conditions, these macrophages maintain good viability and functionality over several days to a week. They can tolerate repeated stimulation with appropriate rest periods, but as with any primary cell type, excessive or prolonged activation may eventually lead to stress or cell death. For experiments involving long-term exposure or multiple rounds of stimulation, we suggest pilot studies to identify optimal schedules and concentrations. Our technical support team is available to help interpret your pilot results and refine your protocols.
Absolutely. Many researchers integrate bone marrow-derived macrophages into co-culture models with rodent neurons, glial cells, or epithelial lines to explore cross-talk between immune and non-immune cells. When combining cell types, it is important to consider the medium composition and environmental conditions that support both populations.
For long-term projects, we can work with you to establish a supply plan that ensures continuity and consistency. Options may include larger initial orders, scheduled production of new lots with comparable characteristics, or custom projects tailored to your specific requirements. Early communication about your projected usage, timeline, and key performance criteria allows us to align production and quality controls with your program needs, reducing the risk of interruptions or unexpected variability.
For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.