MUTZ-3 Cell Line, Differentiated Langerhans Cells (MT-0224-HM23)

Our differentiation protocol is optimized to generate cells that closely resemble primary Langerhans cells, expressing markers such as CD207 and CD1a and exhibiting dendritic morphology. We evaluate antigen uptake, processing, and T-cell activation in internal assays, alongside viability and surface phenotyping.

Absolutely. One of the major advantages of the MUTZ-3 system is its compatibility with high-throughput workflows. The differentiated cells can be seeded in multiwell plates and support automated imaging or plate-reader-based assays. They exhibit uniform behavior across wells when cultured under standardized conditions, enabling reliable comparisons between compounds and efficient generation of large datasets for decision-making.

Yes. For projects that require particular maturation states or tailored cytokine environments, we can adjust differentiation conditions within defined parameters. After customization, we verify viability and key markers. While not every possible condition can be accommodated, we aim to provide flexible solutions that align closely with your experimental design, especially for specialized assays or method development work.