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Osteomacs, Bone-Marrow Macrophages (MT-0224-HM8)

Datasheet

Overview

Description

Osteomacs are a specialized subset of macrophages found within the bone microenvironment. They play crucial roles in bone homeostasis, remodeling, and repair. Osteomacs are characterized by their unique localization at sites of bone remodeling, such as the bone-remodeling units (BRUs) and the bone marrow. These cells are involved in various functions, including the regulation of osteoblast and osteoclast activity, phagocytosis of cellular debris during bone resorption, and secretion of factors that influence bone cell function.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Bone-Marrow

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Are these cells suitable for modeling bone formation and osteo-immunology interactions?

Yes. OsteoMacs naturally regulate osteoblasts and immune-bone crosstalk. Our validated cells demonstrate stable signaling patterns relevant to bone repair, immune-mediated remodeling, and biomaterial testing. They support detailed studies on osteogenesis and local immune integration.

Can these OsteoMacs be used in co-culture systems with bone-forming cells?

Absolutely. They integrate seamlessly with osteoblasts and stromal cells, maintaining signaling patterns crucial for modeling bone deposition and remodeling. Their stable adhesion and cytokine release profiles enable physiologically relevant co-culture experiments.

How do you ensure that OsteoMac batches are suitable for biomaterial-related research?

We confirm that each lot maintains consistent immune and osteogenic-support activity. Their compatibility with scaffolds and substrates is verified through morphology and cytokine-response testing, making them reliable for evaluating osteogenic biomaterials.

The macrophages arrived with excellent viability and well-preserved bone-resident markers
Their functional consistency across experiments helped us reduce variability in our bone remodeling assays.
Technical support provided actionable advice for optimizing seeding density and media composition
With these adjustments, our co-culture results became much more reproducible and informative.
These osteomacs added essential biological context to our tissue-engineering platform
Their presence significantly improved osteoblast differentiation outcomes and produced data that reviewers appreciated in our recent submission.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.