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Mouse Macrophages (Aged), Bone Marrow (MTS-0922-JF25)

Datasheet

Overview

Description

This product is isolated from the bone marrow of pathogen-free laboratory mouse. This product is negative in the tests of mycoplasma, bacteria, fungi and yeast. The expression of CD11b is positive by flow cytometry. It is guaranteed to further culture in the conditions provided by Creative Biolabs. Repeated freezing and thawing of cells is not recommended.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Product Type

Mouse Macrophages

Specification

Cell Source

Bone marrow

Marker expression

Expressed on macrophages, CD11b plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. The expression of CD11b is positive by flow cytometry.

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1 vial

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Notes

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Why would I purchase aged macrophages instead of just using standard adult ones?

Aged macrophages are a critical tool for studying age-related diseases. They exhibit known functional differences compared to young/adult cells, such as a basal pro-inflammatory state (inflammaging), altered metabolic profiles, and impaired phagocytic or efferocytic capacity.

Are these cells M0, or do they have a pre-set phenotype?

They are cultured as bone marrow-derived macrophages (BMDMs), which are technically M0. However, due to their aged source, you should expect them to have a different baseline phenotype (e.g., higher basal IL-6 expression) compared to M0 cells from a young (8-12 week old) mouse.

What is the cell count per vial?

The cell count per vial can vary by lot, as yields from aged mice can be different. Please check the product-specific details or contact our sales team for the exact cell count in the currently available batch.

These aged macrophages were exactly what our inflammaging study needed
Good cells, but be aware they are more sensitive than young BMDMs. Handle them gently. That said, they worked perfectly for our senescent cell co-culture model.
The CoA confirmed they were from 22-month-old B6 mice
This saved us the cost and time of housing mice for 2 years! The viability was surprisingly high for cells from such old animals. They performed beautifully in our metabolic assay.
We saw a clear difference in the basal inflammatory cytokine profile compared to our young controls
A very unique and valuable reagent. We used them to study impaired efferocytosis in aging. The cells definitely showed the expected functional decline. Will be ordering more.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.