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Dural Macrophages, Central Nervous System (MT-0224-HM6)

Datasheet

Overview

Description

Dural macrophages are a specific type of immune cell found within the dura mater, which is the outermost membrane surrounding the brain and spinal cord. These macrophages play a crucial role in the immune defense and maintenance of central nervous system (CNS) homeostasis.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Original

Monocytes

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Central Nervous System

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

How do you maintain batch consistency for studies involving dural inflammation pathways?

We use standardized dissociation protocols, uniform donor criteria, and stringent QC for morphology, cytokine reactivity, and surface markers. Each lot must closely match internal dura-specific benchmarks, ensuring reproducibility in inflammation-focused programs.

Can these macrophages be activated effectively using TLR ligands?

Yes. Dural macrophages respond strongly to a range of TLR agonists. Activation assays show predictable cytokine profiles, enabling researchers to study innate signaling, inflammatory-pathway mapping, and cross-talk with endothelial and fibroblast populations.

How are these cells delivered while keeping phenotype stability intact?

They are cryopreserved in serum-free cryoprotectant and shipped on dry ice. Post-thaw QC ensures high viability and preserved meningeal-immune signatures, supporting consistent experimental integration.

These dural macrophages were essential for modeling the meningeal immune interface in vitro
Their antigen-presentation markers and cytokine release patterns remained stable for several days, enabling us to run multiple stimulation cycles without losing experimental integrity.
The cells exhibited excellent viability and quick adherence, making it easy to set up T-cell co-culture studies
Their physiological responses matched what we expected from published data, which added confidence to our analysis of CNS-peripheral immune communication.
What stood out was how clean the baseline activation was
This allowed us to capture subtle differences between stimuli that previously went undetected. Their behavior was very consistent across replicates and batches.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.