Sensory-nerve-associated Macrophages, Skin and Oral Mucosa (MT-0224-HM22)

Absolutely. Sensory nerve-associated macrophages are highly relevant for experiments examining neuroinflammatory mechanisms. When co-cultured with sensory neurons or placed in complex tissue models, they can be stimulated with inflammatory agents or candidate therapeutics. Changes in neuronal activity, cytokine output, or gene expression can be monitored to understand how macrophage-neuron interactions influence pain-related pathways and tissue sensitivity.

Yes. Researchers routinely use these cells in experimental setups combining electrophysiology or calcium imaging with neuro-immune co-cultures. The macrophages can be seeded in proximity to sensory neurons, and their activation or inhibition can be correlated with changes in neuronal activity. We recommend careful optimization of cell densities and media to support both immune and neuronal components for the duration of such experiments.

Yes. On request, we can pre-expose the macrophages to selected cytokines, neuroactive compounds, or pattern-recognition receptor agonists under controlled conditions. After stimulation, we perform basic checks on viability and activation markers. This service offers ready-to-use cells that already exhibit a disease-relevant activation state.