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Osteoclasts, Bone-Marrow Macrophages (MT-0224-HM9)

Datasheet

Overview

Description

Osteoclasts are specialized cells responsible for the resorption, or breakdown, of bone tissue. They are vital for bone remodeling, which is the process by which old bone is removed and new bone is formed.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Original

Erythro-myeloid Progenitors

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Bone-Marrow

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Are these osteoclasts suitable for anti-resorptive compound screening?

Yes. Their stable resorption performance enables sensitive detection of inhibitory effects from candidate therapeutics. Researchers can reliably assess osteoclast suppression, pathway modulation, and functional changes using our reproducible, well-characterized cell lots.

What identity and functional markers do you check during QC?

We verify TRAP expression, multinucleation levels, bone-resorption activity, and viability. These markers confirm that cells exhibit authentic osteoclast physiology essential for bone-degradation studies.

What culture conditions help maintain osteoclast activity over time?

We recommend medium supplemented with M-CSF and RANKL. These factors support phenotype stability, enabling predictable resorption behavior and long-term functional consistency.

These osteoclasts showed excellent bone-resorbing activity on hydroxyapatite plates and dentine slices
Their TRAP staining and multinucleated morphology were exactly as described, giving us clean functional readouts for inhibitor screening.
Batch consistency was excellent across multiple orders
This helped us maintain continuity in a long-term inhibitor profiling project without needing extensive recalibration.
These osteoclasts are now our preferred choice for bone-resorption studies
Their stability, responsiveness, and strong QC documentation gave us confidence throughout our entire drug discovery workflow.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.