Online Inquiry

Stromal Choroid Plexus Macrophages, Central Nervous System (MT-0224-HM4)

Datasheet

Overview

Description

Stromal choroid plexus macrophages, also known as choroid plexus macrophages (CPMs), are a specialized subset of immune cells found within the choroid plexus of the brain. The choroid plexus is a structure located within the ventricular system of the brain responsible for the production of cerebrospinal fluid (CSF). CPMs play crucial roles in maintaining the homeostasis of the central nervous system (CNS) by participating in immune surveillance, regulation of inflammation, and clearance of cellular debris and pathogens.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Original

Embryonic Progenitors

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Central Nervous System

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

How do your stromal choroid plexus macrophages capture the immune-filtering behavior characteristic of the choroid plexus stroma?

We isolate them through low-stress dissociation optimized for stromal preservation, followed by marker-based enrichment for CD45, CD11b, and MHC-II. Functional screens validate cytokine responsiveness and antigen-presentation profiles, ensuring they reflect the CP stroma's specialized immune surveillance role relevant to CSF barrier research.

Are these cells appropriate for studying aging-related changes in choroid plexus immune function?

Yes. Their preserved inflammatory-response behavior and barrier-associated signaling make them suitable for modeling age-linked CP dysfunction, including altered cytokine secretion, diminished antigen-presentation efficiency, and impaired CSF immune filtration. They provide a relevant platform for mechanistic studies on neuroimmune aging.

Can stromal CP macrophages withstand shear forces in CSF-flow platforms?

Yes. Their stromal origin equips them to tolerate physiological shear levels. We verify performance under controlled flow conditions, confirming stable morphology and preserved cytokine responsiveness, making them ideal for advanced CSF-chip systems or dynamic barrier-interaction studies.

These stromal choroid plexus macrophages significantly improved the biological realism of our CP barrier model
Their ability to modulate epithelial junction proteins and produce measurable TEER changes gave us more confidence in our in vitro readouts. Batch-to-batch consistency was excellent, which is crucial for comparative studies.
Our team appreciated the responsive customer support, which helped us fine-tune medium composition and coating
These optimizations improved cell attachment and reduced background activation. The macrophages behaved very predictably in our co-culture assays, making data interpretation much easier.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.