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Central Vein Macrophages, Liver (MT-0224-HM12)

Datasheet

Overview

Description

Central vein macrophages (CVMs) are a specialized subset of macrophages located in close proximity to the central veins within the liver lobule. They reside within the liver sinusoids, the vascular channels where blood from the hepatic artery and portal vein flows toward the central vein.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Liver

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

How do you confirm their perivenous macrophage identity?

We evaluate marker expression, morphology, viability, and cytokine responsiveness. This ensures researchers receive macrophages with physiologically accurate zone-3 characteristics.

Can these cells be co-cultured with zone-specific hepatocytes?

Absolutely. They naturally interact with perivenous hepatocytes and endothelial cells, supporting advanced models of metabolic stress, inflammation, and local immune regulation.

How stable is their phenotype after cryopreservation?

Our cryopreservation protocol preserves structural integrity and metabolic responsiveness. Post-thaw QC confirms high viability and stable inflammatory behavior for consistent downstream experimentation.

Viability was high, and the cells required minimal recovery time before use
Their cytokine patterns aligned closely with published zonation datasets, which improved our confidence in the results.
The QC documentation included both phenotypic and functional markers
The QC documentation included both phenotypic and functional markers, making it easy to validate the cells before running our experiments. This level of detail significantly streamlined our workflow.
Co-culture with hepatocytes
In co-culture with hepatocytes, these macrophages generated distinct and reproducible inflammatory gradients, helping us better understand zonation-linked immune mechanisms.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.