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Lipid-associated Macrophages, Liver (MT-0224-HM13)

Overview

Description
Lipid-associated macrophages (LAMs) are a distinct subset of tissue-resident macrophages found predominantly in adipose tissue, particularly in visceral adipose depots such as the omentum and mesentery. They are characterized by their unique localization within adipose tissue and their specialized functions in lipid metabolism and immune regulation.
Applications
Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.
Species
Mouse
Product Type
Tissue-specific Macrophages

Specification

Cell Source
Liver
Status
Frozen
Formulation
Cryopreservation medium
Quality Control
Cells are negative for mycoplasma, bacteria, fungi and yeast.
Medium
Recommended medium
Shipping Info
Dry ice
Size
1×10⁶ cells
Handling Notes
Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.
Storage
Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer
This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.
FAQs Customer Reviews Related Products

In which format are the cells shipped, and how do you guarantee cell viability and phenotype after thawing?

We typically supply cryopreserved vials that have undergone a controlled-rate freezing process with validated cryoprotectants. Prior to release, each batch is tested using a standardized thawing protocol to confirm viability, adherence, and functional responsiveness. Shipments are made in dry shippers or on sufficient dry ice with temperature control.

Can these liver macrophages be used in omics-based profiling such as RNA-seq or proteomics?

Absolutely. The cells are processed and stored in a way that preserves RNA and protein integrity, making them suitable for transcriptomic, proteomic, and metabolomic studies. Customers commonly use them to dissect pathway regulation under lipid overload or inflammatory stimulation. We can also provide recommendations on sample handling and timelines to help you obtain high-quality, multi-omics datasets from your experiments.

Do you offer customized pre-conditioning, such as exposure to free fatty acids or inflammatory mediators, before shipment?

Yes. On request, we can apply defined metabolic and inflammatory stimuli to the macrophages, including free fatty acids, cytokines, or other modulators. These treatments are performed under controlled conditions, followed by functional validation to confirm the desired phenotype. This service allows you to receive cells that are already pre-conditioned to a disease-relevant state, saving time and simplifying your workflow.

  • We integrated these liver macrophages into a multi-omics study and were very satisfied with the RNA and protein quality obtained from the cultures
    The cells maintained a stable phenotype across several days, and their lipid-handling capacity was clearly evident. Overall, this product helped us significantly improve the translational relevance of our in vitro metabolic inflammation models.
  • The lipid-associated macrophages provided by the team showed high purity and excellent viability upon arrival
    They adapted well to our imaging-based assays, enabling us to quantify lipid accumulation and inflammatory responses in a reproducible manner. We particularly appreciated the thorough QC report and the practical culture tips included with the shipment.
  • From ordering to technical support, the entire experience was smooth, and we plan to continue using these macrophages in upcoming projects
    We needed a reliable macrophage model that reflected the complexity of fatty liver disease, and this product delivered exactly that. The cells responded predictably to both metabolic stress and anti-inflammatory treatments, supporting our mechanism-of-action studies.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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