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Lamina-propria-associated Macrophages, Gut (MT-0224-HM18)

Datasheet

Overview

Description

Lamina propria-associated macrophages (LPAMs) are a specialized subset of macrophages located within the lamina propria, the connective tissue layer underlying the epithelium of mucosal surfaces in organs such as the gastrointestinal tract and the respiratory tract. LPAMs play pivotal roles in maintaining mucosal immunity, regulating inflammation, and preserving tissue homeostasis within these mucosal compartments.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Original

Fetal Progenitors

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Gut

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Do these macrophages maintain strong phagocytic capacity and viability over time in culture?

Absolutely. Each lot is tested for phagocytosis, and we confirm that the cells maintain robust uptake and viability following thawing.

How do you control batch-to-batch variability in phenotype and inflammatory responsiveness?

We use standardized tissue processing, isolation, and culture protocols, combined with rigorous QC on each batch. This includes viability, marker expression, phagocytic activity, and cytokine responses to defined stimuli. Internal reference controls help us monitor production consistency.

Is it possible to order cells that are pre-primed with inflammatory agents relevant to IBD models?

Yes. We offer custom priming with agents such as LPS, specific cytokine cocktails, or other inflammatory mediators upon request. After priming, we verify that the cells maintain viability and exhibit the expected activation patterns.

Our lab appreciated the high viability and functional stability of the macrophages during multi-day experiments
The cells tolerated repeated stimulations and maintained characteristic inflammatory profiles. The provider's technical support also helped us fine-tune culture conditions and readout timing, which ultimately improved the quality and reproducibility of our data.
We were particularly impressed with the batch-to-batch consistency
We ordered multiple lots over several months, and the macrophages behaved similarly in our standard assays each time. This continuity made it much easier to pool data and compare across experiments, which is crucial for our long-term IBD biomarker discovery program.
The option to receive pre-primed macrophages saved our group considerable time and helped standardize our starting conditions across complex studies
The cells arrived with clear documentation of the priming regimen and activation markers, making it straightforward to incorporate them into our ongoing experiments. Overall, this product has become a central component of our gut immunology workflow.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.