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Alveolar Macrophages, Lung (MT-0224-HM14)

Datasheet

Overview

Description

Alveolar macrophages are a specialized population of macrophages located within the alveoli of the lungs. They are the predominant immune cells present in the airspaces of the lungs and play essential roles in pulmonary immunity, inflammation regulation, and tissue homeostasis.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Lung

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Do the alveolar macrophages preserve their native surfactant-handling and phagocytic functions after isolation and thawing?

Yes. Our isolation workflow is optimized to minimize mechanical and chemical stress, allowing the cells to maintain key features such as surfactant uptake, pathogen clearance, and phagocytosis. Each batch undergoes functional testing.

Are these cells suitable for viral and bacterial infection studies, including influenza or emerging respiratory pathogens?

Absolutely. Alveolar macrophages play a frontline role in host defense within the lung, making them ideal for host-pathogen interaction experiments. They display characteristic cytokine responses and pattern-recognition receptor signaling upon exposure to viruses or bacteria. Researchers commonly use them to evaluate innate immune mechanisms, identify biomarkers of infection, and test the impact of novel prophylactic or therapeutic interventions in vitro.

Are these macrophages compatible with air-liquid interface (ALI) or co-culture systems with epithelial cells?

Yes. The macrophages are well suited for ALI systems and epithelial co-cultures, where they can be added to the apical side or co-seeded with lung epithelia. They adhere well, maintain viability, and show robust responses to environmental and infectious stimuli.

We used these alveolar macrophages in a comprehensive influenza infection model and were very impressed by their responsiveness
Cytokine secretion patterns and gene-expression profiles were highly reproducible between experiments, which gave us confidence in our mechanistic conclusions. The cells also tolerated our air-liquid interface system well and maintained excellent viability over several days.
We conducted a multi-week study using repeated batches of alveolar macrophages, and the batch-to-batch variation was minimal
Cytokine responses to viral mimics were very consistent, and the QC reports provided by the team made it easier to document our workflows. This product has helped us streamline our respiratory immune research and reduce the time we spend troubleshooting primary cell variability.
These macrophages performed extremely well in our aerosolized exposure experiments
They retained their characteristic morphology and produced robust responses to environmental particles and chemical stimuli. Communication with the supplier was smooth, shipping was reliable, and the technical documentation was detailed enough for our whole team to follow with confidence.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.