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Perivascular Macrophages, Central Nervous System (MT-0224-HM3)

Datasheet

Overview

Description

Perivascular macrophages are a subset of macrophages located in the perivascular space, which surrounds blood vessels in various tissues and organs throughout the body. They play essential roles in tissue homeostasis, immune surveillance, and inflammatory responses. These specialized macrophages exhibit distinct phenotypic and functional characteristics compared to other tissue-resident macrophages.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Original

Erythro-myeloid Progenitors

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Central Nervous System

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Are these macrophages suitable for modeling neurovascular inflammation and BBB-immune communication in vitro?

Yes. Their preserved vascular-interface behavior allows realistic co-culture with endothelial and glial cells. They show stable inflammatory responsiveness and barrier-relevant signaling, making them highly useful for BBB integrity studies, leukocyte-trafficking models, and mapping neurovascular immune regulation in disease-focused experiments.

How robust is post-thaw viability, and do the cells recover functional responses quickly?

The cells are cryopreserved in serum-free, macrophage-compatible cryomedium that supports structural integrity during thawing. Post-thaw assessments show strong viability, preserved morphology, and rapid recovery of cytokine responsiveness, enabling researchers to begin downstream BBB, inflammation, or pathogen-interaction studies with minimal recovery time.

Can these perivascular macrophages support studies involving CNS pathogen recognition or vascular immune activation?

Yes. Their preserved innate-sensing pathways allow detailed investigation of pathogen detection, inflammatory cascade initiation, and neurovascular immune signaling. They perform reliably in infection-mimicking assays and help model how perivascular macrophages coordinate early immune responses around CNS blood vessels under pathological conditions.

Overall, the quality was far better than other CNS macrophage suppliers we previously tried.
These cells showed minimal baseline activation, which is essential for our transcriptomic profiling workflows. After stimulation, the cytokine signatures were clear, strong, and highly reproducible. This allowed us to distinguish subtle pathway differences across experimental conditions.
Our team appreciated how consistent these macrophages were across different batches
Morphology, viability, and functional behavior aligned very closely with the QC documentation. They interacted naturally with endothelial monolayers, producing robust yet controlled inflammatory responses, which helped us refine our neuroimmune interface models.
The support team also helped optimize our plating protocol, which improved adhesion and reduced variability between replicates
These perivascular macrophages became a crucial component of our vascular recruitment assays. Their chemokine-driven migration and ability to modulate endothelial activation looked highly physiological.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.