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Erythroblastic Island (EBI) Macrophages, Bone-Marrow (MT-0224-HM7)

Datasheet

Overview

Description

Erythroblastic islands (EBIs) are specialized microenvironments found within the bone marrow where erythropoiesis, the process of red blood cell formation, occurs. These islands consist of a central macrophage surrounded by developing erythroblasts at various stages of maturation. The macrophages within EBIs play crucial roles in supporting and regulating erythropoiesis.

Applications

Numerous types of experimental manipulations, including morphological, gene expression, and physiological studies.

Species

Mouse

Product Type

Tissue-specific Macrophages

Specification

Cell Source

Bone-Marrow

Status

Frozen

Formulation

Cryopreservation medium

Quality Control

Cells are negative for mycoplasma, bacteria, fungi and yeast.

Medium

Recommended medium

Shipping Info

Dry ice

Size

1×10⁶ cells

Handling Notes

Upon receiving, transfer this product directly from dry ice to liquid nitrogen(-150°C~-190°C) and store it in a liquid nitrogen tank.
We cannot guarantee the cell viability if the cells are not treated appropriately according to handling procedure.

Storage

Avoid repeated freezing & thawing.

Product Disclaimer

Product Disclaimer

This product is provided for research only, not suitable for human or animal use.
We ensure the safety of our products, but we still recommend handling any biological materials with standard precautions as if able to spread infectious disease.

FAQs Customer Reviews Related Products

Are these cells suitable for understanding anemia caused by impaired erythropoiesis?

Yes. Their preserved nurturing functions support detailed investigation of erythroid maturation defects, ineffective erythropoiesis, and drug-mediated modulation. They offer a realistic model of the bone-marrow erythroblastic island microenvironment.

What markers verify EBI macrophage identity and functionality?

We assess VCAM-1, CD169, morphology, and adhesion capacity. Functional assays measure erythroblast-binding behavior, ensuring that each lot displays the supporting features required for accurate erythropoiesis research.

Can these cells successfully co-culture with hematopoietic progenitors?

Yes. They integrate well with primary progenitors and maintain stable adhesion and signaling, enabling realistic models of erythroid maturation and facilitating studies on microenvironmental regulation.

We compared these cells with another supplier, and the difference was clear
The purity, adhesion behavior, and cytokine support they provided dramatically improved the consistency of our erythroid maturation assays.
What impressed us most was how well the macrophages maintained erythroid-supportive functions across multiple batches
They enabled meaningful comparisons between different genetic backgrounds and treatment conditions.
The QC data were detailed and extremely helpful, especially the adhesion assays and marker validation
This transparency made it easier to incorporate the cells into our regulated workflows without additional testing delays.

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.