CCL2 & Macrophage

CCR2 is predominantly expressed on the surface of monocytes and macrophages. When CCL2 binds to CCR2, it triggers a signaling cascade within the responding immune cells, directing them toward the source of the chemokine. Once recruited, macrophages can phagocytose pathogens, secrete inflammatory mediators, present antigens to other immune cells, and participate in tissue repair processes. The interaction between CCL2 and macrophages is crucial for the coordination of immune responses to infection, inflammation, and tissue damage. Dysregulation of this interaction can contribute to various inflammatory diseases and conditions, including atherosclerosis, rheumatoid arthritis, and certain types of cancer.

Our Service

Creative Biolabs offers assistance or expertise to create transgenic animals with tissue-specific knockout of CCL2. We aim to help researchers study the role of macrophages in specific tissues or disease models, blocking macrophage recruitment or function through the lack of CCL2. Creative Biolabs offers the following services:

• Animal model
• Flow cytometry, ELISA, western blot
• Macrophage isolation and culture
• scRNA-seq re-analysis
• Chemokine interactome analysis
• Chemotaxis assay with human immune cells
• Efferocytosis assay
• Acute short-term pharmacological CCL2 inhibition

For more Tissue-specific Macrophage Blocking Services, please click here!

Hopefully, the above articles can help you understand our services better. If you have a need in this regard, please contact us immediately. Our experts in the field of macrophages are here to help you around the clock!