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MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with Anti-VISTA antibody (Viral System, Lentivirus) (MTS-1122-YF397)

Datasheet

Cell Properties

Product Overview
As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with Anti-VISTA antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.
Cell Name
Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)
Cell Type
Primary Cell
Cell Species
Mouse
Cell Background
High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type
Checkpoint antibody
Specific Cargo
Anti-VISTA antibody
Target Common Name
VSIR
Target Alternative Names
Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane.
Target Full Name
V-set immunoregulatory receptor
Introduction
Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane.
UniprotID
Q9H7M9
GeneID
64115
Cargo Delivery System Type
Viral System
Cargo Delivery Approach
Lentivirus

Product Properties

Applications
Improve macrophages persist in solid tumors
References
Brom, Victoria C., et al. "The role of immune checkpoint molecules on macrophages in cancer, infection, and autoimmune pathologies." Frontiers in Immunology 13 (2022): 837645. Distributed under Open Access license CC BY 4.0, without modification.
Mycoplasma Testing
Negative
Sterility Testing
Negative
Shipping
Dry ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Restriction
Research use only
Related Products

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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