Macrophage-targeted Nanogel Drug Delivery System
Equipped with state-of-the-art facilities, scientists at Creative Biolabs are dedicated to bringing together years of valuable experience to help our clients with their macrophage-targeted drug delivery system development project. We are committed to providing an integrated solution for macrophage-targeted nanogel drug delivery system development service to reduce the overall project development timeline for our clients.
Introduction of Macrophage-targeted Nanogel Drug Delivery System
In recent years, nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels are hydrogels with a 3D tunable porous structure, with size from 20 to 250 nm. As the ideal candidates for drug delivery, nanogels have several unique characters, such as good biocompatibility, considerable loading capacity, excellent stability, and controlled drug release ability with environmental stimulation. By designing specific chemical structures and different production methods, nanogels can achieve diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), which enables stimuli-responsive drug release in a variety of disease microenvironments. All these unique properties make nanogels capable of drug delivery, diagnostics, and imaging.
Fig.1 Schematic illustration of biomimetic targeting codelivery of Shikonin/JQ1 for reprogramming TME via regulation of metabolism.1,2
Macrophage as Drug Vehicles
Macrophages are the basis of immune defense system of the body, playing important roles in phagocytosis, antigen presentation, and modulation of the immune response. With further understanding of the macrophages and their roles in the body, there is a promise to target macrophage engineering for drug delivery. Several receptors presented on macrophages’ surface, such as dectin-1, mannose, hyaluronate, and tuftsin peptide, have been used to design modified drug delivery systems targeting macrophages.
Creative Biolabs has robustly established a powerful Macrophage Therapeutics Development Platform. We are dedicated to providing high-quality macrophage-targeted nanogels drug delivery system development service to support your project development.
Features of Our Services
-
Extensive experience in macrophage-targeted nanogel drug delivery system development.
-
Advanced techniques and custom assay service.
-
Excellent quality and timely feedback.
For further details, please don't hesitate to contact us and see how we can help you reach your project requirements.
References
-
Kang, Xuejia, et al. "Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy." Pharmaceutics 16.1 (2023): 61.
-
Under Open Access license CC BY 4.0, without modification.
