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VISTA gRNA Lentiviral Particle for Macrophage Engineering (MTS-0124-LX37)

Datasheet

Overview

Description

The ready-to-use VISTA gRNA Lentiviral Particle is packaged using 3rd generation of lentiviral packaging system, which is a research tool for macrophage cell engineering in vivo and in vitro.

Product Type

Virus Particles

Application Scenario

For in vivo and in vitro macrophage engineering

Target Specification

Engineering Approach

Target KO gRNA Contruction Lentivirus

Species

Human

Target

VISTA gRNA

Alternative Names

VSIR

Full Name

V-set immunoregulatory receptor

Introduction

Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane.

UniprotID

Q9H7M9

GeneID

64115

Applications

Prevent cancer cells from evading immune clearance

Reference

Brom, Victoria C et al. "The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies." Frontiers in immunology vol. 13 837645. 28 Mar. 2022, doi:10.3389/fimmu.2022.837645

Product Specification

Packaging System

Lentivirus

Titer

>1E8 TU/mL

Size

200uL; 1mL

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Stored at -80°C for long term.

Handling Notes

Avoid multiple freeze/thaw cycles.

Restriction

RUO

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.