Engineering Approach
Target KO gRNA Contruction Lentivirus
Alternative Names
SN; CD169; SIGLEC-1
Full Name
Sialic acid binding Ig like lectin 1
Introduction
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection.
Applications
Promote the macrophage capability of limiting tumor growth
Reference
Mantovani, Alberto et al. "Macrophages as tools and targets in cancer therapy." Nature reviews. Drug discovery vol. 21,11 (2022): 799-820. doi:10.1038/s41573-022-00520-5
Datasheet