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MacroCargo™ Mouse Bone Marrow-derived Macrophages (BMDM) with pDNA encoding IFN-γ (Nanoparticle System, Magnetic cationic liposomes) (MTS-1122-YF85)

Cell Properties

Product Overview
As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Macrophages (BMDM) carried with pDNA encoding IFN-γ by Nanoparticle System-Magnetic cationic liposomes. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.
Cell Name
Bone Marrow-derived Macrophages (BMDM)
Cell Type
Primary Cell
Cell Species
Mouse
Cell Background
The broad use of transgenic and gene-targeted mice has established bone marrow-derived macrophages (BMDM) as important mammalian host cells for investigation of the macrophages biology.

Cargo Properties

Cargo Type
Cytokine
Specific Cargo
pDNA encoding IFN-γ
Cargo Common Name
IFNG
Cargo Alternative Names
IFG; IFI; IMD69
Cargo Full Name
Interferon gamma
Introduction
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.
UniprotID
GeneID
Cargo Delivery System Type
Nanoparticle System
Cargo Delivery Approach
Magnetic cationic liposomes
Nanoparticle Component
DOTAP, DSPC, cholesterol, iron oxide (II, III).

Product Properties

Applications
Improve the colonic delivery of macrophages and its therapeutic efficacy against colonic inflammatory diseases.
References
Kono, Yusuke et al. "Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field." Drug deliveryvol. 26,1 (2019): 935-943. doi:10.1080/10717544.2019.1662515
Mycoplasma Testing
Negative
Sterility Testing
Negative
Shipping
Dry ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Restriction
Research use only

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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