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MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with Anti-BAG-3 antibody (Viral System, Adenovirus) (MTS-1122-YF395)

Name: MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with Anti-BAG-3 antibody (Viral System, Adenovirus)
SKU: MTS-1122-YF395
Rating: 5 (1 reviews)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with Anti-BAG-3 antibody by Viral System-Adenovirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)

Cell Type

Primary Cell

Cell Species

Mouse

Cell Background

High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-BAG-3 antibody

Target Common Name

BAG3

Target Alternative Names

BIS; MFM6; BAG-3; CAIR-1

Target Full Name

BAG cochaperone 3

Introduction

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

UniprotID

O95817

GeneID

9531

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Adenovirus

Product Properties

Applications

Improve macrophages persist in solid tumors; Increase macrophage infiltrate

References

Brom, Victoria C., et al. "The role of immune checkpoint molecules on macrophages in cancer, infection, and autoimmune pathologies." Frontiers in Immunology 13 (2022): 837645. Distributed under Open Access license CC BY 4.0, without modification.

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only