Engineering Approach
Cytokine Gene Overexpression-Lentivirus
Alternative Names
IFL; IFN; IFNA; IFNA13; leIF D; IFN-ALPHA; IFN-alphaD
Full Name
Interferon alpha 1
Introduction
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia.
Applications
Positive regulator of M1 polarization of macrophage; Improve survival; Resistant to reprogramming by tumor-secreted signals; Promote persistence and activation of endogenous or adoptively transferred NK or T cells
Reference
De Palma, Michele et al. "Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis." Cancer cell vol. 14,4 (2008): 299-311. doi:10.1016/j.ccr.2008.09.004
Datasheet