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MacroCargo™ Human Monocyte-derived Macrophages (MDMs) with Anti-PVRIG antibody (Viral System, Lentivirus) (MTS-1222-YF83)

Name: MacroCargo™ Human Monocyte-derived Macrophages (MDMs) with Anti-PVRIG antibody (Viral System, Lentivirus)
SKU: MTS-1222-YF83
Rating: 5 (1 reviews)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human Monocyte-derived Macrophages (MDMs) carried with Anti-PVRIG antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Monocyte-derived Macrophages (MDMs)

Cell Type

Primary Cell

Cell Species

Human

Cell Background

The culture of human monocyte-derived macrophages (MDMs) represents a tool to study macrophages, with monocytes known to give rise to tissue macrophages influenced by certain environmental cues.

Cargo Properties

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-PVRIG antibody

Target Common Name

PVRIG

Target Alternative Names

CD112R; C7orf15

Target Full Name

PVR related immunoglobulin domain containing

Introduction

Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane.

UniprotID

Q6DKI7

GeneID

79037

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Enhance the immune system against cancer

References

Marin-Acevedo, Julian A., ErinMarie O. Kimbrough, and Yanyan Lou. "Next generation of immune checkpoint inhibitors and beyond." Journal of hematology & oncology 14 (2021): 1-29. Distributed under Open Access license CC BY 4.0, without modification.

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only