Neurotoxic Factor Release Analysis of Microglia and CNS Macrophages

Microglia and CNS macrophages are key players in the immune response. These cells are responsible for monitoring the brain and spinal cord for injury, infection, or disease. These specialized cells have the ability to dynamically adapt to their environment, becoming activated in response to various stimuli, such as infection or injury. Their activation leads to the release of inflammatory mediators and neurotoxic factors, contributing to the progression of neuroinflammatory conditions and neurodegenerative diseases. Creative Biolabs delivers a neurotoxic factor release analysis of microglia and CNS macrophages to help in understanding the intricate mechanisms underlying their activation.

Fig.1 The role of spinal microglia in peripheral nerve damage.¹

Neurotoxic Factor Release Analysis of Microglia and CNS Macrophages at Creative Biolabs

Combined with molecular biology technology, Creative Biolabs develops a neurotoxic factor release analysis platform of microglia and CNS macrophages ranging from nucleotide to protein. To facilitate the subsequent analysis, we provide in vitro isolation and culture services of microglia and CNS macrophages for examining the responses of these cells toward different stimuli, which is helpful for screening out effective therapeutic compounds. Furthermore, customers are able to assess the functions of these cells such as cytotoxic function and oxidative stress function via our neurotoxic factor release analysis service.

In addition, we also provide animal models of neurological diseases, such as Alzheimer's disease, Parkinson's disease, etc., to assist customers in studying the activation of microglia and CNS macrophages and the release of neurotoxic factors during the disease process. Backed up by our experienced scientists and mature technology platform, we have great confidence in presenting each of you with high-quality outcomes in a timely manner. We encourage global customers to inquire and place orders.

Popular Targets for Neurotoxic Factor Release Analysis of Microglia and CNS Macrophages

Here we list a variety of popular targets covering but not restricted to the following:

• Proinflammatory cytokines: TNF-α, IL-6, IL-1β.
• Oxidative stress: ROS, RNS.
• Neurotrophic factors and growth factors: BDNF, NGF.
• Molecules involved in cell death: caspase, apoptosis-inducing factors.

Analysis Technologies Available at Creative Biolabs

As an experienced industrial leader, Creative Biolabs develops a series of technology platforms. For this analysis service, we offer several selective techniques to design for your projects:

Fig.2 Analysis technologies.

Advantages of Our Neurotoxic Factor Release Analysis of Microglia and CNS Macrophages

	Compatible with multiple samples: tissues, blood, cells, cell culture supernatant.
	A variety of analytical techniques are available.
	Strict control of quality.
	Ph.D. research team.
	One-stop customized services.

Potential Applications

• Mechanistic research and therapeutic development in neurodegenerative diseases, neuroinflammation, brain injury, and neuro-infection.
• Effective in evaluating the inhibitory effects of candidate drugs on neurotoxic factors and screening compounds with therapeutic potential.
• Effective in studying the mechanism of nerve regeneration and encouraging nerve regeneration and repair.

As a leader in macrophage research, Creative Biolabs is constantly developing novel service platforms to support global customers' meaningful macrophage projects. If you are attracted by our neurotoxic factor release analysis platform of microglia and CNS macrophages, please feel free to get in touch with us.