MacroCargo™ Mouse Bone Marrow-derived Macrophages (BMDM) with Catalase (Nanoparticle System, Cationic block copolymer) (MTS-1122-YF91)

Cargo Type

Protein

Specific Cargo

Catalase

Cargo Common Name

CAT

Cargo Full Name

Catalase

Introduction

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.

UniprotID

GeneID

Cargo Delivery System Type

Nanoparticle System

Cargo Delivery Approach

Cationic block copolymer

Nanoparticle Component

PEI-PEG

Applications

Carry nanozymes to the brain

References

Batrakova, Elena V et al. "A macrophage-nanozyme delivery system for Parkinson's disease." Bioconjugate chemistry vol. 18,5 (2007): 1498-506. doi:10.1021/bc700184b

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only