MacroCargo™ Mouse Bone Marrow-derived Macrophages (BMDM) with Anti-Tie-2 antibody (Viral System, Lentivirus) (MTS-1122-YF370)

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-Tie-2 antibody

Target Common Name

TEK

Target Alternative Names

TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B

Target Full Name

TEK receptor tyrosine kinase

Introduction

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

UniprotID

GeneID

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Applications

Improve macrophages persist in solid tumors

References

DeNardo, David G, and Brian Ruffell. "Macrophages as regulators of tumour immunity and immunotherapy." Nature reviews. Immunology vol. 19,6 (2019): 369-382. doi:10.1038/s41577-019-0127-6

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only