MacroCargo™ Mouse Bone Marrow-derived Macrophages (BMDM) with IL-13 (Viral System, Lentivirus) (MTS-1222-YF100)

Cargo Type

Cytokine

Specific Cargo

IL-13

Cargo Common Name

IL13

Cargo Alternative Names

P600; IL-13

Cargo Full Name

Interleukin 13

Introduction

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

UniprotID

GeneID

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Applications

Improve survive; Promote persistence and activation of endogenous or adoptively transferred NK or T cells

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only