Creative Biolabs collaborates with your team to transform complex biological questions into precise, high-fidelity datasets. We specialize in isolating MerTK and Axl signaling activities, providing the granular resolution necessary to validate your candidate compounds. Whether you aim to modulate macrophage efferocytosis or reprogram the tumor microenvironment, our infrastructure accelerates your discovery. By tailoring assessment protocols to your specific needs, from monoclonal antibodies to small molecule inhibitors, we support critical decision-making, helping you refine candidate selection and validate mechanistic hypotheses.

The TAM Regulatory Rheostat

The TAM receptor family, comprising Tyro3, Axl, and MerTK, functions as an essential regulatory rheostat for the innate immune system, governing cellular homeostasis and inflammation. By managing processes such as efferocytosis, these receptors maintain a critical balance, preventing aberrant immune activation. Our service provides a sophisticated analytical platform designed to decipher these intricate signaling pathways. We enable researchers to precisely characterize and modulate these receptors, ensuring a deeper understanding of immune regulation. Through our specialized expertise, we provide the insights necessary to translate fundamental biological knowledge into high-fidelity research results.

Comprehensive TAM Insights

Our comprehensive assessment portfolio is designed to provide end-to-end insights into TAM receptor dynamics. We combine cutting-edge biophysical and functional assays to empower your research with precise, reproducible data at every developmental milestone.

Partner with our experts to design a precise, data-driven strategy that accelerates your TAM-targeted research.

Workflow

Our analytical workflow is designed to bridge the gap between initial candidate selection and robust biological validation.

Publication

This study reveals distinct roles of Axl and MerTK in rheumatoid arthritis synovium. In early untreated patients, high AXL expression correlates with low inflammation and paucimmune histology, while MerTK is linked to inflammatory infiltrates. Axl localizes to the lining layer, and its soluble ectodomain is elevated in inflamed joints. Notably, IL-6 blockade modulates Axl expression, suggesting that targeting the Axl pathway could offer therapeutic benefit, particularly in patients refractory to other biologics.

Fig.1 Distinct molecular expression patterns of synovial AXL and MERTK. ¹

Why Choose Us?

Creative Biolabs offers unparalleled technical expertise in RTK signaling, delivering data that is both highly reproducible and actionable for your research programs. Our proprietary platforms are built on rigorous validation protocols, ensuring our assessments of TAM receptor dynamics accurately reflect high-fidelity biological interactions within complex environments. We provide more than just raw data; we deliver the mechanistic insights necessary to navigate the complexities of innate immune modulation. By partnering with us, you gain access to a dedicated team focused on precision, speed, and analytical excellence, ensuring that every result you receive is ready for high-level research decisions.

Experience the Creative Biolabs advantage—schedule a technical consultation and elevate your research outcomes with our specialized analytical platforms.

FAQs

Q1: Can you assess both human and murine TAM receptor interactions?

A1: Yes, we offer cross-species assessment capabilities to ensure your candidates are validated across all relevant research models.

Q2: How do you distinguish between MerTK and Axl signaling in your assays?

A2: We utilize receptor-specific knockdown approaches and highly selective ligand-binding assays to isolate and measure the activity of each receptor individually.

Q3: Do you provide metabolic flux analysis for all candidate types?

A3: Yes, our ECAR and OCR profiling platforms are integrated into our standard service for clients needing to assess metabolic reprogramming.

Customer Review

• Effective Pathway Mapping
  Using Creative Biolabs' TAM assessment service in our research has significantly improved our ability to distinguish between Axl-mediated pro-inflammatory shifts and MerTK-dependent immunosuppression. - Dr. A. S****
• Superior Data Integrity
  Utilizing their metabolic flux analysis allowed us to validate our small molecule inhibitor's mechanism, facilitating our transition to further development models. - Dr. J. M****

Related Services

How to Contact Creative Biolabs

Navigating the complex landscape of TAM receptor signaling requires not only advanced technology but also the specialized expertise to interpret intricate biological data. Creative Biolabs stands ready to be your partner in this endeavor, offering the analytical rigor and technical support needed to move your projects forward.

Click here to contact our scientific team and request a project proposal.

Reference

1. Nerviani, Alessandra, et al. "Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis." Nature communications 15.1 (2024): 2398. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.1038/s41467-024-46564-6