Engineering Approach
Target KO gRNA Contruction Lentivirus
Alternative Names
SLG2; PRO940; SIGLEC-10
Full Name
Sialic acid binding Ig like lectin 10
Introduction
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
Applications
Promote the macrophage capability of limiting tumor growth
Reference
Mantovani, Alberto et al. "Macrophages as tools and targets in cancer therapy." Nature reviews. Drug discovery vol. 21,11 (2022): 799-820. doi:10.1038/s41573-022-00520-5
Datasheet