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MacroCargo™ Rat Alveolar Macrophages with Anti-CEACAM6 antibody (Viral System, Lentivirus) (MTS-1222-YF470)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Rat Rat Alveolar Macrophages carried with Anti-CEACAM6 antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Rat Alveolar Macrophages

Cell Type

Primary Cell

Cell Species

Rat

Cell Background

Alveolar macrophages (AM) are important in the regulation of immune responses in the lung, through their role as scavenger cells and through the production of many bioactive factors.

Cargo Properties

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-CEACAM6 antibody

Target Common Name

CEACAM6

Target Alternative Names

NCA; CEAL; CD66c

Target Full Name

CEA cell adhesion molecule 6

Introduction

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19.

UniprotID

P40199

GeneID

4680

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Reduce inhibition of T cell activation

References

Marin-Acevedo, Julian A et al. "Next generation of immune checkpoint inhibitors and beyond." Journal of hematology & oncology vol. 14,1 45. 19 Mar. 2021, doi:10.1186/s13045-021-01056-8

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only