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IL-23 Lentiviral Particle for Macrophage Engineering (MTS-0124-LX5)

Datasheet

Overview

Description

IL-23 participated in serveral macrophage related functions, including as the positive regulator of M1 polarization of macrophage; improving survive. The ready-to-use IL-23 Lentiviral Particle is packaged using 3rd generation of lentiviral packaging system, aiding in the research of macrophage cell engineering.

Product Type

Virus Particles

Application Scenario

For in vivo and in vitro macrophage engineering

Target Specification

Engineering Approach

Cytokine Gene Overexpression-Lentivirus

Species

Human

Target

IL-23

Alternative Names

IL23; IL-23; Interleukin 23

Full Name

Interleukin 23

Introduction

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19 and p40. The p40 subunit is shared with IL-12. IL-23 is involved in differentiation of Th17 cells in a pro-inflammatory context and especially in the presence of TGF-β and IL-6. Inflammatory macrophages express IL-23R and are activated by IL-23 to produce IL-1, TNF-α, and IL-23 itself. These effects identify IL-23 as a central cytokine in autoimmunity and a highly promising treatment target for inflammatory diseases.

Applications

Positive regulator of M1 polarization of macrophage; Improve survival

Product Specification

Packaging System

Lentivirus

Titer

>1E8 TU/mL

Size

200uL; 1mL

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Stored at -80°C for long term.

Handling Notes

Avoid multiple freeze/thaw cycles.

Restriction

RUO

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.