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MacroCargo™ Human PBMC-derived Monocytes with FPN1 (Viral System, Lentivirus, Fe3O4-nanoparticles) (MTS-1222-YF505)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human PBMC-derived Monocytes carried with FPN1 by Viral System-Lentivirus, Fe3O4-nanoparticles. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

PBMC-derived Monocytes

Cell Type

Primary Cell

Cell Species

Human

Cell Background

Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells.

Cargo Properties

Cargo Type

Protein

Specific Cargo

FPN1

Cargo Common Name

SLC40A1

Cargo Alternative Names

FPN; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3

Cargo Full Name

Solute carrier family 40 member 1

Introduction

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

UniprotID

Q9NP59

GeneID

30061

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus, Fe3O4-nanoparticles

Product Properties

Applications

Induce macrophage polarization into the M1 phenotype; Inhibits tumor growth

References

Wu, Cong et al. "Macrophage-Mediated Delivery of Fe3O4-Nanoparticles: A Generalized Strategy to Deliver Iron to Tumor Microenvironment." Current drug delivery vol. 19,9 (2022): 928-939. doi:10.2174/1567201819666220426085450

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only