Specific Cargo
pDNA encoding IL-18
Cargo Alternative Names
IGIF; IL-18; IL-1g; IL1F4
Cargo Full Name
Interleukin 18
Introduction
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Cargo Delivery System Type
Nanoparticle System
Cargo Delivery Approach
Magnetic cationic liposomes
Nanoparticle Component
DOTAP, DSPC, cholesterol, iron oxide (II, III).
Datasheet