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MacroCargo™ Human Monocyte-derived Macrophages (MDMs) with IL-23 (Viral System, Lentivirus) (MTS-1122-YF37)

Cell Properties

Product Overview
As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human Monocyte-derived Macrophages (MDMs) carried with IL-23 by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.
Cell Name
Monocyte-derived Macrophages (MDMs)
Cell Type
Primary Cell
Cell Species
Human
Cell Background
The culture of human monocyte-derived macrophages (MDMs) represents a tool to study macrophages, with monocytes known to give rise to tissue macrophages influenced by certain environmental cues.

Cargo Properties

Cargo Type
Cytokine
Specific Cargo
IL-23
Cargo Common Name
IL23
Cargo Alternative Names
IL23; IL-23; Interleukin 23
Cargo Full Name
Interleukin 23
Introduction
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19 and p40. The p40 subunit is shared with IL-12. IL-23 is involved in differentiation of Th17 cells in a pro-inflammatory context and especially in the presence of TGF-β and IL-6. Inflammatory macrophages express IL-23R and are activated by IL-23 to produce IL-1, TNF-α, and IL-23 itself. These effects identify IL-23 as a central cytokine in autoimmunity and a highly promising treatment target for inflammatory diseases.
Cargo Delivery System Type
Viral System
Cargo Delivery Approach
Lentivirus

Product Properties

Applications
Positive regulator of M1 polarization of macrophage; Improve survive
Mycoplasma Testing
Negative
Sterility Testing
Negative
Shipping
Dry ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Restriction
Research use only

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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