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MacroCargo™ Human Monocyte-derived Macrophages (MDMs) with Anti-CD47 antibody (Viral System, Lentivirus) (MTS-1122-YF337)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human Monocyte-derived Macrophages (MDMs) carried with Anti-CD47 antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Monocyte-derived Macrophages (MDMs)

Cell Type

Primary Cell

Cell Species

Human

Cell Background

The culture of human monocyte-derived macrophages (MDMs) represents a tool to study macrophages, with monocytes known to give rise to tissue macrophages influenced by certain environmental cues.

Cargo Properties

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-CD47 antibody

Target Common Name

CD47

Target Alternative Names

IAP; OA3; MER6

Target Full Name

CD47 molecule

Introduction

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.

UniprotID

Q08722

GeneID

961

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Improve macrophages persist in solid tumors

References

DeNardo, David G, and Brian Ruffell. "Macrophages as regulators of tumour immunity and immunotherapy." Nature reviews. Immunology vol. 19,6 (2019): 369-382. doi:10.1038/s41577-019-0127-6

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only