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FPN1 shRNA Lentiviral Particle for Macrophage Engineering (MTS-0124-LX16)

Datasheet

Overview

Description

SLC40A1 as a key iron metabolism-related gene in airway macrophages. The pre-made FPN1 shRNA Lentiviral Particle is a research tool to aid in macrophage cell engineering.

Product Type

Virus Particles

Application Scenario

For in vivo and in vitro macrophage engineering

Target Specification

Engineering Approach

Target shRNA Lentivirus

Species

Human

Target

FPN1

Alternative Names

FPN; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3

Full Name

Solute carrier family 40 member 1

Introduction

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

UniprotID

Q9NP59

GeneID

30061

Applications

Induce macrophage polarization into the M1 phenotype; Inhibits tumor growth

Reference

Wu, Cong et al. "Macrophage-Mediated Delivery of Fe3O4-Nanoparticles: A Generalized Strategy to Deliver Iron to Tumor Microenvironment." Current drug delivery vol. 19,9 (2022): 928-939. doi:10.2174/1567201819666220426085450

Product Specification

Packaging System

Lentivirus

Titer

>1E8 TU/mL

Size

200uL; 1mL

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Stored at -80°C for long term.

Handling Notes

Avoid multiple freeze/thaw cycles.

Restriction

RUO

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.